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- 1HERC4 Found to Switch TNF Signals From Survival to Cell Death●Scientists Identify HERC4 as the Molecular Switch That Turns TNF Survival Signals Into Cell Death
Scientists have identified HERC4 as a molecular switch that determines whether TNF, a key immune signalling molecule, promotes cell survival or triggers cell death. The finding offers new insight into inflammation and programmed cell death pathways, and could point toward future treatments for inflammatory and degenerative diseases where TNF signalling goes wrong.