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- 1Hot Spring Metagenome Reveals P450 Enzyme Captured With Oxygen Bound▼Hot Spring Metagenome Yields P450 Enzyme Frozen Mid-Breath With Oxygen on Board
Researchers report a cytochrome P450 enzyme recovered from a hot spring metagenome, crystallized or structurally resolved with oxygen bound at its active site — effectively frozen mid-reaction. The finding offers a rare direct view of how these heme enzymes activate oxygen, a step central to their role in metabolism and biocatalysis, and highlights hot spring microbial communities as a source of novel industrial enzymes.