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lupus
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- 1CAR T cell therapy shows two years free of lupus flares●Two years later, CAR T cell therapy shows promise for life without lupus flares
Researchers at UMass Chan Medical School report that lupus patients treated with CAR T cell therapy have remained free of disease flares two years after receiving the one-time cell-based treatment. The therapy, originally developed for blood cancers, reprograms a patient's own immune cells, and the latest follow-up data suggest it may offer lasting remission in autoimmune disease.
- 2Analysts Argue WILLOW Trial Endpoint, Not Enpatoran, Failed●The WILLOW Trial Didn’t Fail Enpatoran. The Endpoint Did.
Commentary around Merck KGaA's enpatoran is challenging the framing of the WILLOW trial results, arguing the drug was not proven ineffective but that the trial's chosen endpoint failed to capture the treatment effect. The piece says the outcome measure, not the therapy itself, is what fell short, reigniting debate over how lupus clinical trials are designed and judged.
- 3Astronomy podcast wraps up month-long look at Lupus constellation●I am sad to be leaving our month on the Wolf constellation (#LupusConstellation), so here is a cute wolf picture! Learn
A small astronomy podcast is marking the end of its month-long series on the Lupus constellation, known as the Wolf, with a farewell post and a wolf photo. The final installment, a 'Creature Corner' episode about real wolves, has just been released, and listeners are invited to learn more about both the constellation and the animal it is named after.
- 4Mental Health Conditions Tied to More Acute Care Use in Lupus Patients▼Study Links Mental Health Conditions to Greater Acute Care Use Among People With Lupus
A study highlighted by the Lupus Foundation of America has found that people with lupus who also have mental health conditions use acute care services, such as emergency rooms and hospital admissions, at higher rates. The findings point to a link between mental health and more severe disease outcomes in lupus patients, underscoring calls for integrated mental health support in lupus care.