organoids

Drug Discovery News highlights growing debate over reproducibility in advanced 3D cell models, such as organoids and spheroids, which are increasingly used in drug discovery and basic research. Variability in how these models are grown and measured is raising concerns about how reliably results can be repeated across laboratories, prompting calls for better standards and protocols in the field.

The scientific community is discussing efforts to scale liquid chromatography–mass spectrometry for organoid research. Organoids, lab-grown miniature tissue models, produce small sample volumes that make standardized LC–MS analysis difficult, and researchers are exploring workflows and automation to handle larger studies. Advances here could accelerate drug testing and disease modeling by allowing proteomic analysis across many organoid samples at once.