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LDL cholesterol
Trends
- 1
Cholesterol is drawing attention in Germany amid new health reporting. The WHO links elevated LDL cholesterol to 3.6 million deaths, while other coverage highlights an underappreciated cause of high cholesterol: an underactive thyroid. Separate reporting on dementia prevention notes that 45 percent of dementia risk is fundamentally modifiable, tying diet and cardiovascular factors like cholesterol to brain health discussions.
- 2One-Shot CRISPR Therapies Targeting PCSK9 Gain Attention●In-Vivo CRISPR/Base-Editing "One-Shot" Therapies Targeting PCSK9
A newly published review in Current Atherosclerosis Reports examines in-vivo CRISPR and base-editing therapies that target PCSK9, a gene that regulates cholesterol levels. The approach would require only a single treatment to permanently lower LDL cholesterol, potentially replacing daily statins for some patients. Early trials of similar one-time gene-editing cholesterol therapies have generated excitement about the future of cardiovascular prevention.
- 3
New findings indicate that pursuing lower LDL cholesterol targets reduces cardiovascular events by 33% compared with standard goals. The results add weight to the argument that tighter lipid management should become the norm in preventive cardiology, with clinicians and patients weighing more aggressive therapy against risks, costs, and the practicality of sustained low cholesterol levels.
- 4Triglyceride-to-HDL ratio touted as better heart risk marker●Better than checking total CHOLESTEROL The triglyceride-to-HDL ratio (TG/HDL) is one of the best readily available surro
A naturopathic practitioner is arguing that the triglyceride-to-HDL ratio is a better indicator of cardiovascular risk than total cholesterol, describing it as a readily available proxy for insulin resistance and small dense LDL particles. The claim aligns with ongoing debate among clinicians and patients over which lipid measures best predict heart disease and whether standard cholesterol panels miss metabolic risk.