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Mendelian randomization
Trends
- 1Mapping causal biology with Mendelian randomization in the big data era▼Mapping causal biology: Mendelian randomization in the era of big data
A new science release examines Mendelian randomization, a statistical method that uses genetic variants to infer whether biological factors genuinely cause disease rather than merely correlate with it. As genome-scale datasets grow, researchers say the technique is becoming central to identifying causal biology and prioritising drug targets, while debates continue about its assumptions and reliability.