Plex

A proposal to turn the Truman Sports Complex, home of the Kansas City Chiefs and Kansas City Royals, into a year-round sports and entertainment district is drawing attention. The concept would see the stadium area activated beyond game days, with development aimed at making the site a permanent destination for visitors, similar to mixed-use districts built around other major US venues.

A look at the intricacies of building Major League Baseball's schedule, a task balancing 30 teams, travel logistics, broadcast commitments, rivalries and days off. Fans and analysts frequently debate fairness issues, such as uneven opponent strength, long road trips, and how the calendar shapes pennant races and player fatigue across the long 162-game season.

Researchers have published the architecture of the Norrin signaling complex, a molecular assembly involved in retinal vascular development, alongside a structure-guided design of surrogate molecules that can mimic its signaling activity. The work, appearing in Nature, offers a blueprint for engineering therapeutic mimics that could one day help treat diseases linked to faulty Norrin signaling, such as familial exudative vitreoretinopathy.

Researchers report that solving the structure of the Norrin complex has enabled the design of potent engineered signaling surrogates, molecules that mimic the Wnt-related signaling pathway implicated in retinal development and disease, including Norrie disease and familial exudative vitreoretinopathy. The findings could open routes to new therapeutic strategies, though detailed study results and responses from the scientific community remain limited.

Researchers report a newly discovered role for a protein complex in keeping 'jumping genes' — transposable elements — from moving around the genome. The finding sheds light on how cells protect their DNA, with implications for understanding mutations and genetic disease.