✉news ScienceBiology first seen 9 h ago, last 5 h ago, peak #20
Norrin complex structure paves way for engineered signaling surrogates
Original: Norrin complex structure guides potent engineered signaling surrogates
Researchers have determined the structure of the Norrin signaling complex, a protein assembly central to blood vessel development in the eye and ear. With the detailed structural blueprint in hand, scientists can now design potent engineered surrogates that mimic Norrin's activity, an advance with potential relevance for treating disorders such as familial exudative vitreoretinopathy and other Wnt-related conditions.
Why now: The newly solved Norrin complex structure enables rational design of therapeutic signaling molecules, exciting the biomedical research community.
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Evidence
- Norrin complex structure guides potent engineered signaling surrogates · Bioengineer.org
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