autophagy

A new scientific review examines autophagy, the process by which cells recycle their own damaged components. The review argues that manipulating autophagy could benefit patients in some diseases while worsening outcomes in others, highlighting why context matters when developing therapies that target this cellular recycling system.

A study published in Nature presents a multi-scale analysis identifying a shared ox-LDL-autophagy-inflammasome framework connecting osteoporosis and neurodegeneration. The findings suggest the two conditions may share common molecular mechanisms involving oxidized LDL, autophagy dysfunction and inflammasome activation, potentially opening new avenues for research into therapies targeting both bone loss and neurodegenerative disease.

A new study finds that eating less protein does not boost autophagy, the cellular cleanup process often cited in fasting and longevity circles. The finding challenges a popular belief among fitness and diet enthusiasts that restricting protein triggers autophagy, and is drawing attention from people interested in fasting, longevity science and protein intake recommendations.