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Trends
- 1New chromatin tracing method reveals diverse heterochromatin domains▼Single-molecule chromatin tracing reveals a diversity of megabase heterochromatin domains
Researchers report in Nature a single-molecule chromatin tracing technique that maps genome folding directly in single cells. The method reveals a surprising diversity of megabase-scale heterochromatin domains, challenging the view of heterochromatin as a uniform, repetitive compartment. Scientists following the study say the findings refine how chromatin organisation is understood and may affect research into gene regulation and genome stability.
- 2Self-blinking HoT probes enable new chromatin imaging●HoT self-blinking probes for chromatin imaging
Researchers report HoT self-blinking fluorescent probes for imaging chromatin, described in a Nature paper. The probes blink on their own without repeated activation, which should allow longer, higher-resolution imaging of genome organization inside living cells. Scientists studying chromatin structure and super-resolution microscopy are expected to take interest in the method as a simpler alternative to existing single-molecule localization techniques.