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epigenetic clocks
Trends
- 1Scientists probe the network of processes behind aging▼Why do we age — and can science slow it? Aging is not one biological clock. It is a network involving DNA damage, cellul
Aging is being reframed not as a single biological clock but as a network of interacting processes: DNA damage, cellular senescence, mitochondrial dysfunction, chronic inflammation, epigenetic change and declining repair mechanisms. Longevity researchers are now testing which parts of this network can be targeted to slow aging, raising questions about how far interventions might extend healthy lifespan.
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Scientists and commentators are cautioning that epigenetic clocks, the biological-age tests marketed as markers of aging, need rigorous validation before they can support anti-aging claims. The criticism is that measuring methylation patterns does not yet prove an intervention reverses aging, and consumers may be oversold on what these tests can deliver.
- 3RBBP5 Found to Control Cell's 12-Hour Protein Clock▼RBBP5 Emerges as a Master Epigenetic Switch Controlling the Cell’s 12-Hour Proteostasis Clock
Researchers report that the protein RBBP5 acts as a master epigenetic switch governing the cell's 12-hour proteostasis rhythm, a recently identified internal clock that regulates how cells maintain and recycle their proteins. The finding suggests RBBP5 could influence protein quality control, with potential implications for aging and diseases linked to protein misfolding.