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lipid nanoparticles
Trends
- 1Optimized lipid nanoparticles improve in vivo genome editing●Lipid nanoparticles optimized for large RNA cargo and tissue targeting enhance in vivo genome editing
A study published in Nature reports lipid nanoparticles engineered to carry large RNA payloads and target specific tissues, delivering stronger genome editing results in living organisms. The work addresses a key bottleneck in delivering bulky gene-editing RNA payloads safely to target organs. Researchers say the approach could broaden therapeutic applications of in vivo gene editing, though clinical translation remains ahead.
- 2Computational Framework Ranks Safer RNA-LNP Formulations Before Lab Testing●Computational Framework Ranks Safer RNA-LNP Formulations Before the Lab
A new computational framework can rank the safety of RNA-lipid nanoparticle (LNP) formulations in silico, before any laboratory work begins. The approach aims to speed up the design of delivery vehicles used in mRNA vaccines and therapies by predicting which formulations are likely to be safer. Details of validation and who developed it are not yet clear from initial coverage.