phosphoproteome

A study published in Nature presents a large-scale mapping of functional signaling landscapes across the human phosphoproteome. The work charts how phosphorylation sites drive cellular signaling, offering a resource for understanding cell regulation and disease mechanisms. Researchers in molecular biology say such maps could help identify new drug targets, though broader reaction and follow-up are still limited.

Researchers have published a phosphoproteome atlas of human cell lines in Nature, charting the landscape of kinase activity across a broad set of cell models. The resource links phosphorylation patterns to kinase function and is expected to help researchers study cell signalling and support cancer and drug discovery research using cell line models.