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protein complex
Trends
- 1Scientists reveal structure of Norrin signaling complex●Architecture of the Norrin signaling complex and structure-guided surrogate design
A study published in Nature describes the architecture of the Norrin signaling complex and uses that structural information to guide the design of molecular surrogates. Norrin is a signaling protein involved in retinal blood vessel development, and defects in its pathway are linked to inherited eye disease. Researchers say the structural blueprint could support new therapeutic approaches.
- 2Norrin complex structure paves way for engineered signaling surrogates●Norrin complex structure guides potent engineered signaling surrogates
Researchers have determined the structure of the Norrin signaling complex, a protein assembly central to blood vessel development in the eye and ear. With the detailed structural blueprint in hand, scientists can now design potent engineered surrogates that mimic Norrin's activity, an advance with potential relevance for treating disorders such as familial exudative vitreoretinopathy and other Wnt-related conditions.