✉news ScienceBiology first seen 1 d ago, last 12 h ago, peak #1
Context Matters for Drug Targeting
A Nature article argues that drug targeting cannot be understood in isolation from biological context. The piece highlights how a drug's effects depend on the tissue, cell state and disease environment in which its target operates, with implications for how new therapies are developed and evaluated. Researchers say ignoring context helps explain why many promising targets fail in clinical trials despite strong preclinical evidence.
Why now: The article is prompting discussion among researchers about why drug targets that look promising in the lab often fail in patients.
Evidence
- Context matters for drug targeting · Nature
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