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Larger, Male Dogs Age Faster, Epigenetic Study Finds

Original: Epigenetics Underlies Comparatively Accelerated Molecular Aging in Larger and Male Dogs

New research indicates that larger dogs and male dogs undergo accelerated molecular aging compared with smaller dogs and females, and that the difference is rooted in epigenetics—chemical changes to DNA that alter gene activity without changing the genetic code. The findings offer a biological explanation for why big dog breeds have shorter lifespans and may shed light on aging processes more broadly.

Why now: The study offers an epigenetic explanation for a well-known puzzle: why larger dog breeds live shorter lives.

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