✉news ScienceBiology first seen 1 d ago, last 9 h ago, peak #20
Study maps toxicity of protein degrader drugs
Original: Proteome-guided drug discovery maps and mitigates therapeutic degrader toxicity
Researchers have published a proteome-guided drug discovery study in Nature that maps and mitigates the toxicity of therapeutic protein degraders. The work charts which off-target proteins are affected by degrader compounds, allowing scientists to predict and reduce harmful side effects. It is being discussed as a step toward safer targeted protein degradation therapies.
Why now: The new Nature publication offers a method to predict and reduce toxicity in an increasingly important class of drugs.
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