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Lyn Jones group publishes new sulfonyl electrophile chemistry paper
Original: New paper by the group of Lyn Jones. They study the amino acid reactivity and plasma stability of sulfonyl imidazole (Su
The Lyn Jones research group has published a new paper examining the amino acid reactivity and plasma stability of sulfonyl imidazole (SuDEx) and triazole (SuTEx) electrophiles. The study reports that SuDEx electrophiles show enhanced plasma stability alongside notable tyrosine reactivity. The work is relevant to covalent drug discovery, where sulphur-fluoride exchange chemistry is used to target amino acids beyond cysteine.
Why now: Chemistry and drug discovery researchers are sharing the new publication and its findings on emerging electrophile platforms.
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Evidence
- New paper by the group of Lyn Jones. They study the amino acid reactivity and plasma stability of sulfonyl imidazole (SuDEx) and triazole (SuTEx) electrophiles showing enhanced stability and tyrosine reactivity for SuDEx. https:// onlinelibrary.wiley.com/doi/10 .1002/ardp.70353… · Stephanhacker2@mstdn.science · 2
- New paper by the group of Lyn Jones. They study the amino acid reactivity and plasma stability of sulfonyl imidazole (SuDEx) and triazole (SuTEx) electrophiles showing enhanced stability and tyrosine reactivity for SuDEx. https:// onlinelibrary.wiley.com/doi/10 .1002/ardp.70353… · Stephanhacker2@mstdn.science · 2
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