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Scientists explore reactivating mutant p53 to fight cancer
Original: Can mutant p53 be re-activated to treat cancer? Xijun Zhu from the group of Nathanael Gray gave an exciting talk on her
Xijun Zhu, a researcher in Nathanael Gray's group, presented work on reactivating the mutant p53Y220C protein as a cancer treatment. Her approach uses a proximity-inducing small molecule to restore the tumour-suppressor function of the altered protein. The research, published in Nature Communications, was described as an exciting step toward targeting one of the most common mutations in human cancers.
Why now: A new published study and talk present a promising small-molecule strategy to reactivate a key mutated tumour suppressor.
Xijun ZhuNathanael Grayp53Y220CNature Communications
Evidence
- Can mutant p53 be re-activated to treat cancer? Xijun Zhu from the group of Nathanael Gray gave an exciting talk on her research on this topic, in which she activates p53Y220C with a proximity-inducing small molecule. https://www. nature.com/articles/s41467-026 -72165-6 #… · Stephanhacker2@mstdn.science · 3
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