✉news ScienceBiology first seen 10 h ago, last 40 min ago, peak #18
p53 shown to prevent chromothripsis by balancing transcription and replication
Original: p53 keeps a transcription–replication balance that prevents chromothripsis
A report in Nature describes how the p53 tumour suppressor maintains a balance between transcription and DNA replication, and that this balance prevents chromothripsis, the catastrophic shattering of chromosomes seen in many cancers. The finding links a classic cancer-protective protein to a specific mechanism guarding genome integrity, and is drawing attention from researchers studying how tumours arise.
Why now: It is a new Nature publication connecting p53 to prevention of a dramatic form of genome instability relevant to cancer research.
Evidence
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