✉news ScienceBiology first seen 6 d ago, last 5 d ago, peak #15
Rethinking Drug Discovery: Results Before Targets
Original: What If Drug Discovery Started With Results, Not Targets?
Drug discovery traditionally starts by selecting a molecular target and screening compounds against it. A counter-approach, sometimes called phenotypic screening, instead begins with observed results in cells or organisms, then works backwards to identify the mechanism. Discussion is circulating in the biotech and pharmaceutical community about whether results-first methods could uncover effective medicines that target-first research misses.
Why now: Industry debate over whether phenotypic, results-first screening could improve success rates in drug development.
GeneOnlinepharmaceutical industry
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