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BBSome protein complex shown to gate entry into cilia

Original: A role for the BBSome in restricting the entry of non-ciliary proteins into cilia

A new study published in Nature reports that the BBSome, a protein complex linked to Bardet-Biedl syndrome, plays a role in restricting non-ciliary proteins from entering cilia. The findings clarify how cells maintain the distinct composition of these antenna-like organelles, which are involved in signalling. The work may inform research into ciliopathies, the genetic disorders caused by malfunctioning cilia.

Why now: Fresh publication in Nature of findings with relevance to cilia biology and genetic disease research.

BBSomeNatureciliaBardet-Biedl syndrome

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Evidence

• A role for the BBSome in restricting the entry of non-ciliary proteins into cilia · Nature
• A role for the BBSome in restricting the entry of non-ciliary proteins into cilia · Nature

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