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OVOL1/2 genes found to guide early embryo development

Original: OVOL1/2 regulate trophectoderm differentiation during the morula-to-blastocyst transition

Researchers report in Nature that the transcription factors OVOL1 and OVOL2 regulate trophectoderm differentiation as an early mammalian embryo develops from a morula into a blastocyst. The finding clarifies how the first cell lineage decisions are controlled, a key step in understanding fertility, implantation and developmental biology.

Why now: A newly published study in Nature sheds light on how the earliest cell fate decisions in embryo development are controlled.

OVOL1OVOL2Naturetrophectodermblastocyst

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Evidence

• OVOL1/2 regulate trophectoderm differentiation during the morula-to-blastocyst transition · Nature

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