✉news ScienceBiology first seen 2 d ago, last 1 d ago, peak #16
SMARCAL1 protein shown to drive radioresistance and immunosuppression in cancer
Original: Phase separation of SMARCAL1 orchestrates epigenetic reprogramming and methionine metabolism to foster radioresistance and immunosuppression
A study published in Nature reports that SMARCAL1 forms phase-separated condensates that reprogramme epigenetics and methionine metabolism, helping tumour cells resist radiotherapy while suppressing anti-tumour immune responses. The findings suggest SMARCAL1 could be a target for combining radiation treatment with immunotherapy, and researchers are discussing how disrupting this phase separation might sensitise cancers to treatment.
Why now: The newly published Nature study offers a potential new target for overcoming treatment resistance in cancer.
Evidence
API: https://socialmediatrends-api.osmike.com/v1/trends/4236254