✉news ScienceBiology first seen 11 h ago, last 3 h ago, peak #19
Study reveals how cisplatin crosslinks stall transcription
Original: Transcription remodeling and stalling by cisplatin-induced interstrand crosslinks
A study published in Nature examines how cisplatin-induced interstrand crosslinks affect transcription, showing how these DNA lesions remodel and stall the transcription machinery as it encounters the damage. Cisplatin is a widely used chemotherapy drug, and understanding how its crosslinks block RNA polymerase progression provides insight into the drug's mechanism of action and how cells respond to such DNA damage.
Why now: New molecular-level findings on how a major chemotherapy drug damages and blocks transcription are of interest to cancer and DNA repair researchers.
Evidence
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