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Prozac use in children for depression traced to single flawed trial

Original: Prozac use for childhood depression skewed by single flawed medical trial

A Nature report argues that widespread prescribing of Prozac (fluoxetine) for childhood depression rests largely on one early clinical trial now judged methodologically flawed. Commentators say the finding raises questions about how a single weak study shaped decades of treatment guidance for adolescents, and are calling for re-examination of the evidence base behind paediatric antidepressant use.

Why now: A new Nature article challenging the evidence behind a widely prescribed children's antidepressant is drawing attention to medical research reliability.

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