✉news ScienceBiology first seen 1 d ago, last 21 h ago, peak #13

Circular RNA protein found to suppress ferroptosis in chronic brain ischemia

Original: CircAbcc1-encoded ABCC1-677aa modulates DLX1 to suppress ferroptosis in chronic cerebral ischemia

Researchers report that a circular RNA, CircAbcc1, encodes a protein called ABCC1-677aa that modulates the DLX1 molecule to suppress ferroptosis, an iron-dependent form of cell death, in chronic cerebral ischemia. The finding, published in Nature, points to a previously unknown mechanism that could inform future therapies for reduced blood flow to the brain and the neuronal damage it causes.

Why now: The study reveals a novel circular RNA-encoded protein mechanism protecting brain cells from ferroptosis, a hot topic in cell death research.

CircAbcc1ABCC1-677aaDLX1Nature

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Evidence

• CircAbcc1-encoded ABCC1-677aa modulates DLX1 to suppress ferroptosis in chronic cerebral ischemia · Nature

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