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Outside-the-Box Science Sparked a Revolution in Targeting KRAS

Original: A New Way In: How Outside-the-box Science Sparked a Revolution in Targeting KRAS

The American Association for Cancer Research is highlighting how unconventional research approaches led to the first successful drugs targeting KRAS, a cancer-driving protein long considered undruggable. After decades of failure, inhibitors such as sotorasib and adagrasib have now reached patients with KRAS-mutated cancers, marking one of the most significant recent shifts in oncology drug development.

Why now: KRAS inhibitors are a major recent breakthrough in cancer treatment, and the story of how they were achieved is drawing attention from the cancer research community.

American Association for Cancer ResearchKRASsotorasibadagrasib

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